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Take Combipres by mouth with or without food as directed by your doctor, usually once or twice daily. It is best to avoid taking this medication within 4 hours of your bedtime to avoid having to get up to urinate. Consult doctor, pharmacist, or other healthcare professional if you have questions about your dosing schedule.

The dosage is based on your medical condition and response to treatment.

If you also take certain drugs to lower your cholesterol (bile acid-binding resins such as cholestyramine or colestipol), take Combipres at least 2 hours before or at least 4 hours after these medications.

Use Combipres (Clonidine, Chlorthalidone) regularly to get the most benefit from it. To help you remember, use it at the same time(s) each day. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick.

Do not stop taking Combipres (Clonidine HCl, Chlorthalidone) without consulting your doctor. You may experience symptoms such as nervousness, agitation, shaking, and headache. A rapid rise in blood pressure may also occur if the drug is suddenly stopped. The risk is greater if you have used this drug for a long time or in high doses, or if you are also taking a beta blocker (such as atenolol). There have also been rare reports of severe, possibly fatal reactions (such as stroke) from stopping this drug too quickly. Therefore, it is important that you do not run out of this medication or miss any doses. Tell your doctor or pharmacist right away if you are unable to take the medication (for example, due to vomiting). To prevent any reactions while you are stopping treatment with this drug, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details. Report any new or worsening symptoms right away.

When used for a long time, Combipres may not work as well and may require different dosing or an additional medication. Talk with your doctor if this medication stops working well (such as your blood pressure readings remain high or increase).

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